Principales voies de régulationde la satiété et de la faim au niveau hypothalamique

In this schematic diagram of the brain, the dashed lines indicate hormonal inhibitory effects, and the solid lines stimulatory effects. The paraventricular and arcuate nuclei each contain neurons that are capable of stimulating or inhibiting food intake. Y1R and Y2R denote the Y1 and Y2 subtypes of the neuropeptide Y (NPY) receptor, MC4R melanocortin 4 receptor, PYY peptide YY3–36, GHsR growth hormone secretagogue receptor, AgRP agouti-related protein, POMC proopiomelanocortin, -MSH -melanocyte–stimulating protein, LEPR leptin receptor, and INSR insulin receptor.(NEJM (2003) 349:926-928)

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